Hemorrhoid Degrees of Pregnant Women in the Use of Suppository Phaleria macrocarpa
DOI:
https://doi.org/10.31965/infokes.Vol22.Iss4.1664Keywords:
Haemoroid, Phaleria macrocarpa, Pregnant, SuppositoryAbstract
Increased progesterone levels during pregnancy can lead to haemorrhoids, which require proper management to minimize risks to both the mother and fetus. Since haemorrhoidectomy is not a suitable option for pregnant women, alternative treatments with minimal side effects are needed. This study aimed to evaluate the effectiveness of Phaleria macrocarpa suppositories in reducing the degree of haemorrhoids in pregnant women. This study employed a true experimental design with a cross-sectional approach. The study population consisted of pregnant women selected through purposive sampling. Data were collected using observation sheets and analyzed using the Wilcoxon test. The results study show that among pregnant women who used standard suppositories, 23 participants (71.8%) showed no change in the degree of haemorrhoids, while 9 participants (28.8%) experienced a reduction in severity. In contrast, all 32 participants (100%) who used Phaleria macrocarpa suppositories experienced a decrease in haemorrhoid severity. Statistical analysis showed a significant difference (p < 0.05) between the two groups, with a p-value of 0.0013, indicating that Phaleria macrocarpa suppositories were significantly more effective in reducing haemorrhoids compared to standard suppositories. The conclusion is Phaleria macrocarpa suppositories effectively reduce the severity of haemorrhoids in pregnant women and may serve as a safer alternative to conventional treatments. Further research with larger sample sizes and long-term follow-ups is recommended to validate these findings and explore the potential mechanisms of Phaleria macrocarpa in haemorrhoid treatment.
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Abdul-Kadir, R., & Gomez, K. (2022). Reproductive Health and Hemostatic Issues in Women and Girls with Congenital Factor VII Deficiency: A Systematic Review. Journal Of Thrombosis And Haemostasis, 20(12), 2758–2772. https://doi.org/10.1111/Jth.15872
Alara, O. R., Mudalip, S. A., & Olalere, O. A. (2017). Optimization of mangiferin extrated from Phaleria macrocarpa fruits using response surface methodology. Journal of Applied Research on Medicinal and Aromatic Plants, 5, 82-87. https://doi.org/10.1016/j.jarmap.2017.02.002
Andarkhor, P., Sadeghi, A., Khodadoost, M., Kamalinejad, M., Gachkar, L., Abdi, S., & Zargaran, A. (2019). Effects of Terminalia chebula Retz. in treatment of hemorrhoids: A double–blind randomized placebo–controlled clinical trial. European Journal of Integrative Medicine, 30, 100935. https://doi.org/10.1016/j.eujim.2019.100935
Andrean, D., Prasetyo, S., Kristijarti, A. P., & Hudaya, T. (2014). The extraction and activity test of bioactive compounds in Phaleria macrocarpa as antioxidants. Procedia Chemistry, 9, 94-101. https://doi.org/10.1016/j.proche.2014.05.012
Astriyani, W., Surjowardojo, P., & Susilorini, T. E. (2017). Daya hambat ekstrak buah mahkota dewa (Phaleria macrocarpa L.) dengan pelarut ethanol dan aquades terhadap bakteri Staphylococcus aureus penyebab mastitis pada sapi perah. TERNAK TROPIKA Journal of Tropical Animal Production, 18(2), 8-13. https://doi.org/10.21776/Ub.Jtapro.2017.018.02.2
Awad, A., Goyanes, A., Orlu, M., Gaisford, S., & Basit, A. W. (2023). 3D printed infliximab suppositories for rectal biologic delivery. International Journal of Pharmaceutics: X, 5, 100176. https://doi.org/10.1016/J.Ijpx.2023.100176
Awad, A., Hollis, E., Goyanes, A., Orlu, M., Gaisford, S., & Basit, A. W. (2023). 3D printed multi-drug-loaded suppositories for acute severe ulcerative colitis. International Journal of Pharmaceutics: X, 5, 100165. https://doi.org/10.1016/j.ijpx.2023.100165
Beksac, K., Aydin, E., Uzelpasacı, E., Akbayrak, T., & Ozyuncu, O. (2018). Hemorrhoids and related complications in primigravid pregnancy. Journal of Coloproctology (Rio de Janeiro), 38(3), 179-182. https://doi.org/10.1016/J.Jcol.2018.03.002
Bohl, J. L., Saleeby, R. G., & Herline, A. J. (2007). Acute Hemorrhoidal Crisis. Seminars in Colon and Rectal Surgery, 18(3), 197–201. https://doi.org/10.1053/J.Scrs.2007.07.010
Buckshee, K., Takkar, D., & Aggarwal, N. (1997). Micronized flavonoid therapy in internal hemorrhoids of pregnancy. International Journal of Gynecology & Obstetrics, 57(2), 145-151. https://doi.org/10.1016/S0020-7292(97)02889-0
Carolina, L., Syamsuri, K., & Manawan, E. (2014). Hemorhoid Dalam Kehamilan. MKS, 46(2), 164-170.
Christina, Y. I., Rifa’i, M., Widodo, N., & Djati, M. S. (2022). The combination of Elephantopus scaber and Phaleria macrocarpa leaves extract promotes anticancer activity via downregulation of ER-α, Nrf2 and PI3K/AKT/mTOR pathway. Journal of Ayurveda and Integrative Medicine, 13(4), 100674. https://doi.org/10.1016/j.jaim.2022.100674
Deshpande, R., Swaroop, M., Muralimohan, M., & Shetty, A. (2022). A randomised controlled trial to evaluate the effect of Gandhaka Rasayana rectal suppository in post operative pain management in ano-rectal disorders. Journal of Ayurveda and Integrative Medicine, 13(1), 100485. https://doi.org/10.1016/J.Jaim.2021.07.001
Ebrahimi, N., Vohra, S., Gedeon, C., Akoury, H., Bernstein, P., Pairaudeau, N., ... & Koren, G. (2011). The fetal safety of hydrocortisone-pramoxine (Proctofoam-HC) for the treatment of hemorrhoids in late pregnancy. Journal of Obstetrics and Gynaecology Canada, 33(2), 153-158. https://doi.org/10.1016/S1701-2163(16)34802-2
Gold, D., Nicolay, L., Avian, A., Greimel, E., Balic, M., Pristauz-Telsnigg, G., ... & Trutnovsky, G. (2023). Vaginal laser therapy versus hyaluronic acid suppositories for women with symptoms of urogenital atrophy after treatment for breast cancer: a randomized controlled trial. Maturitas, 167, 1-7. https://doi.org/10.1016/j.maturitas.2022.08.013
Haider, R. (2023). Hemorrhoids the Clinical Practice. J, Surgical Case Reports and Images, 6(5), 2690-1897. https://doi.org/10.31579/2690-1897/166
Hinchee-Rodriguez, K., Duong, A., & Kraus, C. N. (2022). Local Management Strategies For Inflammatory Vaginitis in Dermatologic Conditions : Suppositories , Dilators , And Estrogen Replacement. JAAD International, 9, 137–138. https://doi.org/10.1016/J.Jdin.2022.09.004
Jiang, H., Hao, X., Xin, Y., & Pan, Y. (2017). Comparison of clinical outcomes of multi-point umbrella suturing and single purse suturing with two-point traction after procedure for prolapse and hemorrhoids (PPH) surgery. International Journal of Surgery, 47, 77-82. https://doi.org/10.1016/J.Ijsu.2017.09.053
Katata-Seru, L., Ojo, B. M., Okubanjo, O., Soremekun, R., & Aremu, O. S. (2020). Nanoformulated Eudragit lopinavir and preliminary release of its loaded suppositories. Heliyon, 6(5), e03890. https://doi.org/10.1016/J.Heliyon.2020.E03890
Kavitha, N., Chen, Y., Kanwar, J. R., & Sasidharan, S. (2017). In situ morphological assessment of apoptosis induced by Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) in MDA-MB-231 cells by microscopy observation. Biomedicine & Pharmacotherapy, 87, 609-620. https://doi.org/10.1016/J.Biopha.2016.12.127
Kavitha, N., Vijayarathna, S., Oon, C. E., Chen, Y., Kanwar, J. R., Punj, V., & Sasidharan, S. (2018). MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools. Journal of ethnopharmacology, 213, 118-131. https://doi.org/10.1016/j.jep.2017.11.009
Lie, M. R., Kreijne, J. E., Dijkstra, G., Löwenberg, M., van Assche, G., West, R. L., ... & Dutch Initiative on Crohn and Colitis. (2020). No superiority of tacrolimus suppositories vs beclomethasone suppositories in a randomized trial of patients with refractory ulcerative proctitis. Clinical Gastroenterology and Hepatology, 18(8), 1777-1784. https://doi.org/10.1016/J.Cgh.2019.09.049
Lim, Y. P., Pang, S. F., Yusoff, M. M., Mudalip, S. K. A., & Gimbun, J. (2019). Correlation between the extraction yield of mangiferin to the antioxidant activity, total phenolic and total flavonoid content of Phaleria macrocarpa fruits. Journal of Applied Research on Medicinal and Aromatic Plants, 14, 100224. https://doi.org/10.1016/J.Jarmap.2019.100224
Parés, D., Coll, C. M., Troya, J., Queral, L. A., Lopez-Negre, J. L., & Martinez-Franco, E. (2021). Influence of bowel habit and hormonal changes on the development of hemorrhoidal disease during pregnancy and the postdelivery period: a prospective cohort study. Diseases of the Colon & Rectum, 64(6), 724-734. https://doi.org/10.1097/DCR.0000000000001822
Poskus, T., Sabonyte-Balsaitiene, Z., Jakubauskiene, L., Jakubauskas, M., Stundiene, I., Barkauskaite, G., Smigelskaite, M., Jasiunas, E., Ramasauskaite, D., Strupas, K., & Drasutiene, G. (2022). Preventing hemorrhoids during pregnancy: a multicenter, randomized clinical trial. BMC pregnancy and childbirth, 22(1), 374. https://doi.org/10.1186/s12884-022-04688-x
Rao, S. S., Qureshi, W. A., Yan, Y., & Johnson, D. A. (2022). Constipation, hemorrhoids, and anorectal disorders in pregnancy. Official journal of the American College of Gastroenterology| ACG, 117(10S), 16-25. https://doi.org/10.14309/ajg.0000000000001962
Salusso, P., Testa, V., Mochet, S., Arezzo, A., Allaix, M. E., Salzano, A., ... & Mistrangelo, M. (2021). Management of hemorrhoidal disease in special conditions: A word of caution. Reviews on Recent Clinical Trials, 16(1), 22-31. https://doi.org/10.2174/1574887115666200406121308
Sheikh, P., Régnier, C., Goron, F., & Salmat, G. (2020). The prevalence, characteristics and treatment of hemorrhoidal disease: results of an international web-based survey. Journal of comparative effectiveness research, 9(17), 1219-1232. https://doi.org/10.2217/cer-2020-0159
Shwter, A. N., Abdullah, N. A., Alshawsh, M. A., El-Seedi, H. R., Al-Henhena, N. A., Khalifa, S. A., & Abdulla, M. A. (2016). Chemopreventive effect of Phaleria macrocarpa on colorectal cancer aberrant crypt foci in vivo. Journal of ethnopharmacology, 193, 195-206. https://doi.org/10.1016/j.jep.2016.08.002
Zhang, Q., & Zhang, L. (2021). A Multicenter, Randomized, Open And Positive Parallel Controlled Clinical Study Of Clotrimazole Vaginal Expansion Suppository And Vaginal Tablet In The Treatment Of Mild And Moderate Vulvovaginal Candidiasis. Fertility and Sterility, 116(3), e254. https://doi.org/10.1016/J.Fertnstert.2021.07.681
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