The Effect of Self-Resignation Exercise on the Quality of Life of HIV Patients
DOI:
https://doi.org/10.31965/infokes.Vol23.Iss4.1994Keywords:
Self-Resignation Exercise, HIV, NLR, QOLAbstract
People living with HIV/AIDS (PLWHA) are vulnerable to anxiety related to their illness, which can adversely affect inflammatory markers such as the Neutrophil-to-Lymphocyte Ratio (NLR) and overall quality of life (QOL). This study aimed to examine the effect of Self-Resignation Exercise as a complementary and holistic intervention on NLR and quality of life among HIV patients experiencing anxiety disorders. A randomized controlled trial with a pretest–posttest control group design was conducted in the Infection Subsection of Dr. Moewardi Hospital, Surakarta, starting in January 2024. Participants were HIV patients with anxiety disorders who had stable physical conditions and received routine treatment, and they were randomly assigned to a control group (n = 20) and an intervention group (n = 20). Anxiety levels were assessed using the Hamilton Rating Scale for Anxiety (HRSA), quality of life was measured with the WHOQOL-BREF, and inflammatory status was evaluated through blood tests to determine NLR. The intervention group received Self-Resignation Exercise in addition to standard care, while the control group received standard care alone. The results demonstrated a significant reduction in anxiety levels and a significant improvement in quality of life in the intervention group compared to the control group, with all measured outcomes showing p-values < 0.001. In conclusion, Self-Resignation Exercise is effective in reducing anxiety and improving quality of life in people living with HIV/AIDS, indicating its potential as a complementary approach to enhance both psychological well-being and overall health status.
Downloads
References
Aghaie, N., SeyedAlinaghi, S., Montazeri, A., & Moghadam, Z. B. (2021). Effectiveness of mindfulness-based stress reduction training on resilience in Iranian HIV-positive women: a clinical trial. HIV & AIDS Review. International Journal of HIV-Related Problems, 20(3), 195-200. https://doi.org/10.5114/hivar.2021.108834
Ali, R., Gwayed, B., E, K., & Mohamed, R. (2023). Effect of Self-Learning Intervention on Knowledge, Attitudes and Care Provided among Nurses Caring for HIV AIDs Patients in Fever Hospitals. Tanta Scientific Nursing Journal, 29(22), 62–84. https://doi.org/10.21608/tsnj.2023.306347
Aranda, A., Bastida, J., Ballester-Hernandez, Y., Jasmin, J., Martinez, S. S., Martin, H., ... & Baum, M. (2023). The Neutrophil to Lymphocyte Ratio Is Associated With Hs-CRP in a Sample of Underrepresented Individuals From the Miami Adult Studies on HIV (MASH) Cohort. Current Developments in Nutrition, 7, 101462. https://doi.org/10.1016/j.cdnut.2023.101462
Asfar, T., Alcaide, M. L., Jones, D. L., McClure, L. A., Brewer, J., Lee, D. J., & Carrico, A. (2022). HIV patients’ perceptions of a potential multi-component mindfulness-based smoking cessation smartphone application intervention. Plos one, 17(8), e0271946. https://doi.org/10.1371/journal.pone.0271946
Avci, G. U., Kanat, B. B., Can, G., Erdincler, D. S., Doventas, A., & Yavuzer, H. (2023). The relationship between malnutrition and neutrophil–to-lymphocyte ratio in hospitalized older patients. Bratislava Medical Journal, 124(7), 498–502. https://doi.org/10.4149/BLL_2023_076
Corno, G., Espinoza, M., & Maria Banos, R. (2019). A narrative review of positive psychology interventions for women during the perinatal period. Journal of Obstetrics and Gynaecology, 39(7), 889-895. https://doi.org/10.1080/01443615.2019.1581735
Ethel, R. A., AS, W. S., & Sofro, M. A. (2016). Hubungan Tingkat Kecemasan dengan Kualitas Hidup Pasien HIV/AIDS di RSUP Dr. Kariadi Semarang. Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal), 5(4), 1623-1633. Retrieved from: https://ejournal3.undip.ac.id/index.php/medico/article/view/15910
Fauziah, F., Wafa, K., & Panuntun, M. S. (2022). Relaksasi Tingkat Stres Pasien Bekam Melalui Pendekatan Senam Tawakal. Spiritualita, 6(1), 39–50. https://doi.org/10.30762/spiritualita.v6i1.389
Fook, K. D., Araújo, M. J. A. M., Muniz, A. C. D. S., Carvalho, M. M. D., Morais, A. C. C. D. D., Araújo, D. R. D., ... & Monteiro, S. C. M. (2024). Neutrophil/lymphocyte and platelet/lymphocyte ratio in seropositive women for human immunodeficiency virus (HIV) and human papillomavirus (HPV) coinfection. Revista do Instituto de Medicina Tropical de São Paulo, 66, e67. https://doi.org/10.1590/S1678-9946202466067
Gaebler, C., Nogueira, L., Stoffel, E., Oliveira, T. Y., Breton, G., Millard, K. G., ... & Nussenzweig, M. C. (2022). Prolonged viral suppression with anti-HIV-1 antibody therapy. Nature, 606(7913), 368-374. https://doi.org/10.1038/s41586-022-04597-1
Hamid, M. S. A., & Rajah, S. J. J. (2015). Effects of progressive resistance exercises on quality of life, body composition and muscle strength in patients with HIV. Sains Malaysiana, 44(10), 1473-1479. https://doi.org/10.17576/jsm-2015-4410-13
Huang, H., Zhang, L., Tu, L., Zhang, X., Zhong, H., Liu, Q., Liu, Y., & Chen, H. (2024). The Impact of Stigma on Self-Management Behavior Among People with HIV in China: The Role of Social Support and Self-Esteem. AIDS Patient Care and STDs, 38(9), 453–462. https://doi.org/10.1089/apc.2024.0104
Imtiaz, F., Shafique, K., Mirza, S. S., Ayoob, Z., Vart, P., & Rao, S. (2012). Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine, 5(1), 1-6. https://doi.org/10.1186/1755-7682-5-2
Jannesar, K., Roosta, Y., Masoudi, N., Asghari, R., Rasouli, J., & Soraya, H. (2024). Anti-cancer effect of memantine as adjunctive therapy in metastatic colon cancer: A pilot randomized controlled clinical trial. MedRxiv. https://doi.org/10.1101/2024.09.01.24312896
Kaplan, H. I., Sadock, B. J., & Grebb, J. A. (2010). Sinopsis psikiatri: Ilmu pengetahuan perilaku psikiatri klinis. Tangerang: Binarupa Aksara.
Kaunda-Khangamwa, B. N., Kapwata, P., Malisita, K., Munthali, A., Chipeta, E., Phiri, S., & Manderson, L. (2020). Adolescents living with HIV, complex needs and resilience in Blantyre, Malawi. AIDS Research and Therapy, 17(1), 35. https://doi.org/10.1186/s12981-020-00292-1
Kurniawati, V. V., Harioputro, D. R., & Susanto, A. J. (2022). Evaluasi Kadar Sel Cd4, Viral Load, Dan Neutrophil Lymphocyte Ratio (Nlr) Terhadap Infeksi Oportunistik Pada Pasien HIV/AIDS. Biomedika, 14(2), 99–107. https://doi.org/10.23917/biomedika.v14i2.17299
Marando, F., Gualberti, G., Costanzo, A. M., di Luzio Paparatti, U., Franzetti, M., Ammassari, A., Antinori, A., & Galli, M. (2016). Discrepancies between physician’s perception of depression in HIV patients and self-reported CES-D-20 assessment: the DHIVA study. AIDS Care, 28(2), 147–159. https://doi.org/10.1080/09540121.2015.1080794
Mikkelsen, H. T., Haraldstad, K., Helseth, S., Skarstein, S., Småstuen, M. C., & Rohde, G. (2020). Health-related quality of life is strongly associated with self-efficacy, self-esteem, loneliness, and stress in 14–15-year-old adolescents: a cross-sectional study. Health and Quality of Life Outcomes, 18(1), 352. https://doi.org/10.1186/s12955-020-01585-9
Miners, A., Phillips, A., Kreif, N., Rodger, A., Speakman, A., Fisher, M., ... & Lampe, F. C. (2014). Health-related quality-of-life of people with HIV in the era of combination antiretroviral treatment: a cross-sectional comparison with the general population. The lancet HIV, 1(1), e32-e40. https://doi.org/10.1016/S2352-3018(14)70018-9
Moraes, L. J., Miranda, M. B., Loures, L. F., Mainieri, A. G., & Mármora, C. H. C. (2018). A systematic review of psychoneuroimmunology-based interventions. Psychology, Health & Medicine, 23(6), 635–652. https://doi.org/10.1080/13548506.2017.1417607
Prianggandanni, M. A. V., Lestari, A. A. W., Wande, I. N., Mahartini, N. N., & Herawati, S. (2023). Correlation between T-lymphocyte CD4+ and Total Lymphocyte Count (TLC), hemoglobin, Neutrophil to Lymphocyte Ratio (NLR) and T-lymphocyte CD4+/CD8+ ratio in HIV patients at Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Bali, Indonesia. Bali Medical Journal, 12(2), 2017-2021. https://doi.org/10.15562/bmj.v12i2.4342
Siswanto, A., Asdie, A. H., Novyanto, R., Kardin, L., Sahara, Y., Kaban, D. Y., ... & Dwinata, M. (2024). The Impact of Latihan Pasrah Diri/Self Surrender Practice (LPD) in Sleep Quality and Inflammatory Markers in Diabetes Mellitus Type 2 Patients Without Depression: A Randomized Controlled Trial. Integrative Medicine, 23(4), 16–22.
Siswanto, A., Juffrie, M., Rianto, B. U. D., & Asdie, H. A. H. (2020). Effect of self surrender practice on insulin resistance in individuals withtype 2 diabetes mellitus without depression: asingle-blinded randomized controlled trial. J Med Sci, 52(1), 68-80. https://doi.org/10.19106/JMedSci005201202008
Suyata, S., Singh, P., Hudari, H., Indrajaya, T., & Sari, N. P. (2023). The Relationship between Neutrophil Lymphocyte Ratio and Hepatitis C Virus RNA in Hepatitis C Coinfected HIV Patients Receiving Direct-Acting Antiviral Therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 7(1), 3058-3062. https://doi.org/10.37275/bsm.v7i1.761
Szuhany, K. L., & Simon, N. M. (2022). Anxiety disorders: a review. JAMA, 328(24), 2431-2445. https://doi.org/10.1001/jama.2022.22744
Talbott, J. A., Ballenger, J.C., Buckley, P.F., Frances, R.J., Krupnick, J.L., & Mack, A.H. (2012). Year Book of Psychiatry and Applied Mental Health 2012. Philadelphia: Elsevier.
Tegene, Y., Mengesha, S., Toma, A., Geleta, D., & Spigt, M. (2023). A qualitative study exploring perceptions of people living with HIV using antiretroviral therapy on self-management of healthy nutrition and the related healthcare service in Ethiopia. AIDS Care, 35(8), 1139–1148. https://doi.org/10.1080/09540121.2023.2188160
UNAIDS. (2024). New UNAIDS report shows AIDS pandemic can be ended by 2030, but only if leaders boost resources and protect human rights now. UNAIDS. Retrieved from: https://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2024/july/20240722_global-aids-update
Verma, C. V., Kamble, A., & Krishnan, V. (2018). HIV-Positive Individuals: Exercise, Yoga and Quality of Life. International STD Research & Reviews, 7(3), 1–7. https://doi.org/10.9734/isrr/2018/42404
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 JURNAL INFO KESEHATAN
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright notice
Ownership of copyright
The copyright in this website and the material on this website (including without limitation the text, computer code, artwork, photographs, images, music, audio material, video material and audio-visual material on this website) is owned by JURNAL INFO KESEHATAN and its licensors.
Copyright license
JURNAL INFO KESEHATAN grants to you a worldwide non-exclusive royalty-free revocable license to:
- view this website and the material on this website on a computer or mobile device via a web browser;
- copy and store this website and the material on this website in your web browser cache memory; and
- print pages from this website for your use.
- All articles published by JURNAL INFO KESEHATAN are licensed under the Creative Commons Attribution 4.0 International License. This permits anyone to copy, redistribute, remix, transmit and adapt the work provided the original work and source is appropriately cited.
JURNAL INFO KESEHATAN does not grant you any other rights in relation to this website or the material on this website. In other words, all other rights are reserved.
For the avoidance of doubt, you must not adapt, edit, change, transform, publish, republish, distribute, redistribute, broadcast, rebroadcast or show or play in public this website or the material on this website (in any form or media) without appropriately and conspicuously citing the original work and source or JURNAL INFO KESEHATAN prior written permission.
Permissions
You may request permission to use the copyright materials on this website by writing to [email protected].
Enforcement of copyright
JURNAL INFO KESEHATAN takes the protection of its copyright very seriously.
If JURNAL INFO KESEHATAN discovers that you have used its copyright materials in contravention of the license above, JURNAL INFO KESEHATAN may bring legal proceedings against you seeking monetary damages and an injunction to stop you using those materials. You could also be ordered to pay legal costs.
If you become aware of any use of JURNAL INFO KESEHATAN copyright materials that contravenes or may contravene the license above, please report this by email to [email protected]
Infringing material
If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to [email protected].
